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ENSPRYNG Important Safety Information

What is ENSPRYNG?
ENSPRYNG is a prescription medicine used to treat neuromyelitis optica spectrum disorder (NMOSD) in adults who are aquaporin-4 (AQP4) antibody positive. It is not known if ENSPRYNG is safe and effective in children.

Who should not receive ENSPRYNG?
Do not take ENSPRYNG if you:

• are allergic to ENSPRYNG or any of the ingredients in ENSPRYNG.
• have an active hepatitis B infection.
• have active or untreated inactive (latent) tuberculosis.

What is the most important information I should know about ENSPRYNG?
ENSPRYNG may cause serious side effects including:

• Infections: ENSPRYNG can increase your risk of serious infections some of which can be life-threatening. Talk to your healthcare provider if you have or think you have an infection.
• Your healthcare provider should test you for hepatitis and tuberculosis (TB) before you start taking ENSPRYNG.
• All required vaccinations should be completed before starting ENSPRYNG.
• Increased liver enzymes: Your healthcare provider should order blood tests to check your liver enzymes before and while you are taking ENSPRYNG.
• Low neutrophil count: ENSPRYNG can cause a decrease in your neutrophil counts in your blood. Neutrophils are white blood cells that help the body fight off bacterial infections.
• Serious allergic reactions: Serious allergic reactions that may be life-threatening have happened with other medicines like ENSPRYNG.

What are the most common side effects of ENSPRYNG?
The most common side effects of ENSPRYNG include:

These are not all the possible side effects of ENSPRYNG.
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects to Genentech at 1-888-835-2555.

For more information, go to www.ENSPRYNG.com or call 1-844-NSPRYNG.

For additional safety information, please see the full Prescribing Information and Medication Guide.