Program Update!

Effective January 1st, Genentech will be updating the co-pay program benefit period. The program will be moving from a 12-month benefit to a calendar year benefit (January to December).

Patient benefit will automatically renew annually for all patients enrolled in the program on January 1st.

For more information, please call the Help Desk at 800-636-0373.

The information contained in this section of the site is intended for US specialty pharmacy representatives only. Click "OK" if you are a specialty pharmacy representative.

Indication and Important Safety Information  |  Prescribing Information

Downloadable Forms

Check Request Form

Complete this form when you are seeking reimbursement after paying the provider for your treatment. The instructions for using the program with these providers are included on the form.

Indication and Important Safety Information

ENSPRYNG Important Safety Information

What is ENSPRYNG?
ENSPRYNG is a prescription medicine used to treat neuromyelitis optica spectrum disorder (NMOSD) in adults who are aquaporin-4 (AQP4) antibody positive. It is not known if ENSPRYNG is safe and effective in children.

Who should not receive ENSPRYNG?
Do not take ENSPRYNG if you:

  • are allergic to ENSPRYNG or any of the ingredients in ENSPRYNG.
  • have an active hepatitis B infection.
  • have active or untreated inactive (latent) tuberculosis.

What is the most important information I should know about ENSPRYNG?
ENSPRYNG may cause serious side effects including:

  • Infections: ENSPRYNG can increase your risk of serious infections some of which can be life-threatening. Talk to your healthcare provider if you have or think you have an infection.
    • Your healthcare provider should test you for hepatitis and tuberculosis (TB) before you start taking ENSPRYNG.
    • All required vaccinations should be completed before starting ENSPRYNG.
  • Increased liver enzymes: Your healthcare provider should order blood tests to check your liver enzymes before and while you are taking ENSPRYNG.
  • Low neutrophil count: ENSPRYNG can cause a decrease in your neutrophil counts in your blood. Neutrophils are white blood cells that help the body fight off bacterial infections.
  • Serious allergic reactions: Serious allergic reactions that may be life-threatening have happened with other medicines like ENSPRYNG.

What are the most common side effects of ENSPRYNG?
The most common side effects of ENSPRYNG include:

  • sore throat, runny nose (nasopharyngitis)
  • rash
  • fatigue
  • extremity pain
  • headache
  • upper respiratory tract infection
  • nausea
  • inflammation of the stomach lining (gastritis)
  • joint pain (arthralgia)

These are not all the possible side effects of ENSPRYNG.
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects to Genentech at 1-888-835-2555.

For more information, go to www.ENSPRYNG.com or call 1-844-NSPRYNG.

For additional safety information, please see the full Prescribing Information and Medication Guide.

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Questions about this program?

Call (844) NSPRYNG (844-677-7964)
9 a.m.–8 p.m. ET, Monday through Friday (except major holidays)
 
For questions about ENSPRYNG, please call (844) NSPRYNG (844-677-7964).

 
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